Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels

Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels

Abstract Background Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s disease (AD) biomarker changes. Examination of postmortem brains of participants with antemortem plasma p-tau levels remains critical to understa...

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Bibliographic Details
Main Authors: Melissa E. Murray, Christina M. Moloney, Naomi Kouri, Jeremy A. Syrjanen, Billie J. Matchett, Darren M. Rothberg, Jessica F. Tranovich, Tiffany N. Hicks Sirmans, Heather J. Wiste, Baayla D. C. Boon, Aivi T. Nguyen, R. Ross Reichard, Dennis W. Dickson, Val J. Lowe, Jeffrey L. Dage, Ronald C. Petersen, Clifford R. Jack, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Michelle M. Mielke
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s Disease
Neuropathology
Blood biomarker
Phosphorylated Tau
Neurofibrillary Tangles
Amyloid-β
Online Access:https://doi.org/10.1186/s13024-022-00578-0

Internet

https://doi.org/10.1186/s13024-022-00578-0

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