Time-dependent specific molecular signatures of inflammation and remodelling are associated with trimethylamine-N-oxide (TMAO)-induced endothelial cell dysfunction

Time-dependent specific molecular signatures of inflammation and remodelling are associated with trimethylamine-N-oxide (TMAO)-induced endothelial cell dysfunction

Abstract Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). This study aims to clarify the time-dependent molecular pathways by which TMAO mediates endothelial dysfunction thr...

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Bibliographic Details
Main Authors: Meyammai Shanmugham, Arun George Devasia, Yu Ling Chin, Kang Hao Cheong, Eng Shi Ong, Sophie Bellanger, Adaikalavan Ramasamy, Chen Huei Leo
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-46820-7

Internet

https://doi.org/10.1038/s41598-023-46820-7

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