Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction
Monosodium glutamate (MSG) is one of the most frequently used food additives that endanger public health. The antioxidant, hyperlipidemic, and cytoprotective properties of <i>Lepidium sativum</i> seeds (LSS) as a natural remedy can minimize the harmful effects of MSG. This study investig...
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MDPI AG
2023-11-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/22/4129 |
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| author | Manal Salah El-Gendy Eman Sobhy El-Gezawy Ahmed A. Saleh Rashed A. Alhotan Mohammed A. A. Al-Badwi Elsayed Osman Sewlim Hussein Hossam M. El-Tahan In Ho Kim Sungbo Cho Sara Mahmoud Omar |
| author_facet | Manal Salah El-Gendy Eman Sobhy El-Gezawy Ahmed A. Saleh Rashed A. Alhotan Mohammed A. A. Al-Badwi Elsayed Osman Sewlim Hussein Hossam M. El-Tahan In Ho Kim Sungbo Cho Sara Mahmoud Omar |
| author_sort | Manal Salah El-Gendy |
| collection | DOAJ |
| description | Monosodium glutamate (MSG) is one of the most frequently used food additives that endanger public health. The antioxidant, hyperlipidemic, and cytoprotective properties of <i>Lepidium sativum</i> seeds (LSS) as a natural remedy can minimize the harmful effects of MSG. This study investigated the potential protective effect of LSS against MSG-induced hepatotoxicity in rats. Male albino Sprague Dawley rats (<i>n</i> = 24) were equally divided into four groups for 30 days: the control group (G1) received a basal diet without supplement, group (G2) was fed a basal diet + MSG (30 g/kg b.w.) as a model group, group (G3) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (30 g/kg b.w.), and group (G4) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (60 g/kg b.w.). LSS enhanced serum alkaline phosphatase activity as well as total cholesterol, triglyceride, and glucose levels. It can decrease peroxide content in serum lipids and inhibit glutathione reductase and superoxide dismutase in hepatic cells. The dietary supplementation with LSS provided cytoprotection by enhancing the histoarchitecture of the liver and decreasing the number of apoptotic cells. Due to their antioxidant and anti-apoptotic properties, LSS effectively protect against the hepatotoxicity of MSG. These findings are of the highest significance for drawing attention to incorporating LSS in our food industry and as a health treatment in traditional medicine to combat MSG-induced hepatic abnormalities. |
| first_indexed | 2024-03-09T16:49:45Z |
| format | Article |
| id | doaj.art-4d822fd4616941648e615611d1f03ad3 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T16:49:45Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-4d822fd4616941648e615611d1f03ad32023-11-24T14:42:09ZengMDPI AGFoods2304-81582023-11-011222412910.3390/foods12224129Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic DysfunctionManal Salah El-Gendy0Eman Sobhy El-Gezawy1Ahmed A. Saleh2Rashed A. Alhotan3Mohammed A. A. Al-Badwi4Elsayed Osman Sewlim Hussein5Hossam M. El-Tahan6In Ho Kim7Sungbo Cho8Sara Mahmoud Omar9Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, EgyptNutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, EgyptDepartment of Poultry Production, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh 333516, EgyptDepartment of Animal Production, College of Food & Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi ArabiaDepartment of Animal Production, College of Food & Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi ArabiaAlKhumasia for Feed and Animal Products, Riyadh-Olaya-Al Aqareyah 2-Office 705, P.O. Box 8344, Riyadh 11982, Saudi ArabiaAnimal Production Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki 12611, EgyptAnimal Resource and Science Department, Dankook University, Cheonan 31116, Republic of KoreaAnimal Resource and Science Department, Dankook University, Cheonan 31116, Republic of KoreaNutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Tanta 31732, EgyptMonosodium glutamate (MSG) is one of the most frequently used food additives that endanger public health. The antioxidant, hyperlipidemic, and cytoprotective properties of <i>Lepidium sativum</i> seeds (LSS) as a natural remedy can minimize the harmful effects of MSG. This study investigated the potential protective effect of LSS against MSG-induced hepatotoxicity in rats. Male albino Sprague Dawley rats (<i>n</i> = 24) were equally divided into four groups for 30 days: the control group (G1) received a basal diet without supplement, group (G2) was fed a basal diet + MSG (30 g/kg b.w.) as a model group, group (G3) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (30 g/kg b.w.), and group (G4) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (60 g/kg b.w.). LSS enhanced serum alkaline phosphatase activity as well as total cholesterol, triglyceride, and glucose levels. It can decrease peroxide content in serum lipids and inhibit glutathione reductase and superoxide dismutase in hepatic cells. The dietary supplementation with LSS provided cytoprotection by enhancing the histoarchitecture of the liver and decreasing the number of apoptotic cells. Due to their antioxidant and anti-apoptotic properties, LSS effectively protect against the hepatotoxicity of MSG. These findings are of the highest significance for drawing attention to incorporating LSS in our food industry and as a health treatment in traditional medicine to combat MSG-induced hepatic abnormalities.https://www.mdpi.com/2304-8158/12/22/4129monosodium glutamate (MSG)<i>Lepidium sativum</i> seeds (LSS)hepatotoxicityantioxidantdietary studyglutathione reductase |
| spellingShingle | Manal Salah El-Gendy Eman Sobhy El-Gezawy Ahmed A. Saleh Rashed A. Alhotan Mohammed A. A. Al-Badwi Elsayed Osman Sewlim Hussein Hossam M. El-Tahan In Ho Kim Sungbo Cho Sara Mahmoud Omar Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction Foods monosodium glutamate (MSG) <i>Lepidium sativum</i> seeds (LSS) hepatotoxicity antioxidant dietary study glutathione reductase |
| title | Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction |
| title_full | Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction |
| title_fullStr | Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction |
| title_full_unstemmed | Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction |
| title_short | Investigating the Chemical Composition of <i>Lepidium sativum</i> Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction |
| title_sort | investigating the chemical composition of i lepidium sativum i seeds and their ability to safeguard against monosodium glutamate induced hepatic dysfunction |
| topic | monosodium glutamate (MSG) <i>Lepidium sativum</i> seeds (LSS) hepatotoxicity antioxidant dietary study glutathione reductase |
| url | https://www.mdpi.com/2304-8158/12/22/4129 |
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