Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression

Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression

Myeloproliferative neoplasms (MPN) are chronic cancers of the hematopoietic stem cells in the bone marrow, and patients often harbor elevated numbers of circulating platelets (PLT). We investigated the frequencies of circulating PLT-lymphocyte aggregates in MPN patients and the effect of PLT-binding...

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Bibliographic Details
Main Authors: Ana Micaela Carnaz Simões, Morten Orebo Holmström, Pia Aehnlich, Anne Rahbech, Marlies J. W. Peeters, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjær, Christina Ellervik, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Per thor Straten
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
platelets
platelet-bound T cells
platelet-T cell aggregates
Myeloproliferative Neoplasms (MPN)
CALR mutation
JAK2 mutation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.866610/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.866610/full

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