Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury

Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury

Abstract. Background:. Dysfunction of the gap junction channel protein connexin 43 (Cx43) contributes to myocardial ischemia/reperfusion (I/R)-induced ventricular arrhythmias. Cx43 can be regulated by small ubiquitin-like modifier (SUMO) modification. Protein inhibitor of activated STAT Y (PIASy) is...

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Bibliographic Details
Main Authors: Tingting Wang, Jinmin Liu, Chenchen Hu, Xin Wei, Linlin Han, Afang Zhu, Rong Wang, Zhijun Chen, Zhengyuan Xia, Shanglong Yao, Weike Mao, Rongman Jia, Xiuyuan Hao
Format: Article
Language:English
Published: Wolters Kluwer 2023-06-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000002618

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http://journals.lww.com/10.1097/CM9.0000000000002618

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