Preparation and characterization of naproxen solid dispersion using different hydrophilic carriers and in-vivo evaluation of its analgesic activity in mice

Preparation and characterization of naproxen solid dispersion using different hydrophilic carriers and in-vivo evaluation of its analgesic activity in mice

Background: Solid dispersion (SD) has been used conventionally as a successful technique for improving the dissolution profile and bioavailability of poorly water-soluble drugs. The aim of this study was to progress the dissolution rate and bioavailability of naproxen (BCS class II) by SD technique....

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Bibliographic Details
Main Authors: Monia Akter Nupur, Mst Mahfuza Rahman, Khurshida Akter, Khadiza Binte Hanif, Jinat Fatema Sharna, Md Shahin Sarker, Mir Imam Ibne Wahed
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Heliyon
Subjects:
Naproxen
Solid dispersion
PEG 8000
Sodium starch glycolate
Analgesic activity
solvent evaporation method
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023026397

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http://www.sciencedirect.com/science/article/pii/S2405844023026397

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