Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β<sup>−</sup>-emitter <sup>177</sup>Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (<s...

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Bibliographic Details
Main Authors: Min-Ying Lin, Hsin-Hua Hsieh, Jyh-Cheng Chen, Chuan-Lin Chen, Nin-Chu Sheu, Wen-Sheng Huang, Shinn-Ying Ho, Ting-Wen Chen, Yi-Jang Lee, Chun-Yi Wu
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
brachytherapy
<sup>177</sup>Lu-DTPA-pAuNS
head and neck cancer
photothermal therapy
Online Access:https://www.mdpi.com/1999-4923/13/11/1903

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https://www.mdpi.com/1999-4923/13/11/1903

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