En Route to Targeted Ribosome Editing to Replenish Skin Anchor Protein LAMB3 in Junctional Epidermolysis Bullosa

En Route to Targeted Ribosome Editing to Replenish Skin Anchor Protein LAMB3 in Junctional Epidermolysis Bullosa

Severe junctional epidermolysis bullosa is a rare genetic, postpartum lethal skin disease, predominantly caused by nonsense/premature termination codon (PTC) sequence variants in LAMB3 gene. LAMB3 encodes LAMB3, the β subunit of epidermal–dermal skin anchor laminin 332. Most translational reads of a...

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Bibliographic Details
Main Authors: Bjoern Wimmer, Andreas Friedrich, Katharina Poeltner, Genevieve Edobor, Claudia Mosshammer, Gazmend Temaj, Adriana Rathner, Thomas Karl, Jan Krauss, Joerg von Hagen, Christopher Gerner, Michael Breitenbach, Helmut Hintner, Johann W. Bauer, Hannelore Breitenbach-Koller
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:JID Innovations
Subjects:
Genodermatoses
Drug development
Blistering disease
Epidermolysis bullosa
Genetic diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026723000668

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http://www.sciencedirect.com/science/article/pii/S2667026723000668

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