Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression

Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression

Psoriasis is an incurable chronic inflammatory disease that requires new interventions. Here, we found that fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion by single-cell multi-omics analysis. The natural small molecule celastrol was screened to in...

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Bibliographic Details
Main Authors: Yuyu Zhu, Lixin Zhao, Wei Yan, Hongyue Ma, Wanjun Zhao, Jiao Qu, Wei Zheng, Chenyang Zhang, Haojie Du, Meng Yu, Ning Wan, Hui Ye, Yicheng Xie, Bowen Ke, Qiang Xu, Haiyan Sun, Yang Sun, Zijun Ouyang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Psoriasis
Fibroblast
CCL2
Celastrol
LRP1
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000024

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http://www.sciencedirect.com/science/article/pii/S2211383525000024

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