CDK6 is activated by the atypical cyclin I to promote E2F‐mediated gene expression and cancer cell proliferation

CDK6 is activated by the atypical cyclin I to promote E2F‐mediated gene expression and cancer cell proliferation

Cyclin‐dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner CDKs remain elusive. Here, we conducted a yeast two‐...

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Bibliographic Details
Main Authors: Eva Quandt, Núria Masip, Sara Hernández‐Ortega, Abril Sánchez‐Botet, Laura Gasa, Ainhoa Fernández‐Elorduy, Sara Plutta, Joan Marc Martínez‐Láinez, Samuel Bru, Pau M. Munoz‐Torres, Martin Floor, Jordi Villà‐Freixa, May C. Morris, August Vidal, Alberto Villanueva, Josep Clotet, Mariana P. C. Ribeiro
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Molecular Oncology
Subjects:
atypical cyclins
CDK6
E2F
palbociclib
retinoblastoma
Online Access:https://doi.org/10.1002/1878-0261.13438

Internet

https://doi.org/10.1002/1878-0261.13438

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