A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country

A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country

Shigellosis is a mild-to-severe diarrheal infection, caused by the genus Shigella, and is responsible for significant morbidity and mortality worldwide. We evaluated the safety and immunogenicity of an investigational Shigella sonnei vaccine (1790GAHB) based on generalized modules for membrane antig...

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Bibliographic Details
Main Authors: Christina W. Obiero, Augustin G. W. Ndiaye, Antonella Silvia Sciré, Bonface M. Kaunyangi, Elisa Marchetti, Ann M. Gone, Lena Dorothee Schütte, Daniele Riccucci, Joachim Auerbach, Allan Saul, Laura B. Martin, Philip Bejon, Patricia Njuguna, Audino Podda
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
Shigella sonnei
1790GAHB vaccine
generalized modules for membrane antigen
safety
immunogenicity
Shigella-endemic settings
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01884/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01884/full

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