Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice
Polychlorinated biphenyls (PCBs) are synthetic biphenyl compounds with high toxicity. There are a total of 209 homologs, among which 2,3’,4,4’,5-pentachlorobiphenyl (PCB118) is one of the dioxin-like PCBs. PCB118 can accumulate in pregnant mice, leading to fetus directly exposure during development....
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651321007648 |
| _version_ | 1818689490591416320 |
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| author | Yu-Rong Tao Yong-Tao Zhang Xiao-Ying Han Lin Zhang Li-Gang Jiang Ying Ma Ling-Jiao Meng Qi-Long He Shu-Zhen Liu |
| author_facet | Yu-Rong Tao Yong-Tao Zhang Xiao-Ying Han Lin Zhang Li-Gang Jiang Ying Ma Ling-Jiao Meng Qi-Long He Shu-Zhen Liu |
| author_sort | Yu-Rong Tao |
| collection | DOAJ |
| description | Polychlorinated biphenyls (PCBs) are synthetic biphenyl compounds with high toxicity. There are a total of 209 homologs, among which 2,3’,4,4’,5-pentachlorobiphenyl (PCB118) is one of the dioxin-like PCBs. PCB118 can accumulate in pregnant mice, leading to fetus directly exposure during development. The stage of migration of mouse primordial germ cells ranges from 8.5 to 13.5 days of pregnancy, which is the stage undergoing a genome-wide DNA demethylation process. In this study, the mice were exposed to 20 μg/kg/day and 100 μg/kg/day PCB118 from 8.5 to 13.5 days of pregnancy. During the embryo stage at 18.5 days (E18.5 days), the expression level of DNA methyltransferase 1 (Dnmt1) was reduced in the testes, and the DNA methylation level in mouse testes were also decreased. We found that the seminiferous tubules showed vacuolization and that the sperm deformity rate increased in the treated groups compared with the control group in 7-week-old mice. Because exposure to PCB118 during pregnancy causes damage to the reproductive system of male offspring mice, attention should be devoted to the toxicity transmission of persistent environmental pollutants such as PCBs. |
| first_indexed | 2024-12-17T12:10:56Z |
| format | Article |
| id | doaj.art-4d99737cf1ac4b6eb6c92d7ebc546d60 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-17T12:10:56Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-4d99737cf1ac4b6eb6c92d7ebc546d602022-12-21T21:49:25ZengElsevierEcotoxicology and Environmental Safety0147-65132021-11-01224112652Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male miceYu-Rong Tao0Yong-Tao Zhang1Xiao-Ying Han2Lin Zhang3Li-Gang Jiang4Ying Ma5Ling-Jiao Meng6Qi-Long He7Shu-Zhen Liu8Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, ChinaShandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, China; Shandong First Medical University, Jinan 250062, Shandong, ChinaShandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, ChinaShandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, ChinaInfertility Center, Qilu Hospital of Shandong University, Jinan 250012, ChinaShandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, ChinaShandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, ChinaCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; Corresponding author at: Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, China; Corresponding author.Polychlorinated biphenyls (PCBs) are synthetic biphenyl compounds with high toxicity. There are a total of 209 homologs, among which 2,3’,4,4’,5-pentachlorobiphenyl (PCB118) is one of the dioxin-like PCBs. PCB118 can accumulate in pregnant mice, leading to fetus directly exposure during development. The stage of migration of mouse primordial germ cells ranges from 8.5 to 13.5 days of pregnancy, which is the stage undergoing a genome-wide DNA demethylation process. In this study, the mice were exposed to 20 μg/kg/day and 100 μg/kg/day PCB118 from 8.5 to 13.5 days of pregnancy. During the embryo stage at 18.5 days (E18.5 days), the expression level of DNA methyltransferase 1 (Dnmt1) was reduced in the testes, and the DNA methylation level in mouse testes were also decreased. We found that the seminiferous tubules showed vacuolization and that the sperm deformity rate increased in the treated groups compared with the control group in 7-week-old mice. Because exposure to PCB118 during pregnancy causes damage to the reproductive system of male offspring mice, attention should be devoted to the toxicity transmission of persistent environmental pollutants such as PCBs.http://www.sciencedirect.com/science/article/pii/S0147651321007648PCB118TestisSpermatogoniaMale reproductive toxicityDNA methylation |
| spellingShingle | Yu-Rong Tao Yong-Tao Zhang Xiao-Ying Han Lin Zhang Li-Gang Jiang Ying Ma Ling-Jiao Meng Qi-Long He Shu-Zhen Liu Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice Ecotoxicology and Environmental Safety PCB118 Testis Spermatogonia Male reproductive toxicity DNA methylation |
| title | Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice |
| title_full | Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice |
| title_fullStr | Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice |
| title_full_unstemmed | Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice |
| title_short | Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice |
| title_sort | intrauterine exposure to 2 3 4 4 5 pentachlorobiphenyl alters spermatogenesis and testicular dna methylation levels in f1 male mice |
| topic | PCB118 Testis Spermatogonia Male reproductive toxicity DNA methylation |
| url | http://www.sciencedirect.com/science/article/pii/S0147651321007648 |
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