Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
<p>Abstract</p> <p>Background</p> <p>A mutation in the <it>BRI2/ITM2b</it> gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-04-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | http://www.molecularneurodegeneration.com/content/7/1/19 |