Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

<p>Abstract</p> <p>Background</p> <p>A mutation in the <it>BRI2/ITM2b</it> gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis....

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Tamayev Robert, D’Adamio Luciano
स्वरूप: लेख
भाषा:English
प्रकाशित: BMC 2012-04-01
श्रृंखला:Molecular Neurodegeneration
ऑनलाइन पहुंच:http://www.molecularneurodegeneration.com/content/7/1/19