Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development

Regulation of the IL-5 receptor alpha (<i>IL5RA</i>) gene is complicated, with two known promoters (P1 and P2) driving transcription, and two known isoforms (transmembrane and soluble) dichotomously affecting the signaling potential of the protein products. Here, we sought to determine t...

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Bibliographic Details
Main Authors: Kimberly G. Laffey, Jian Du, Adam G. Schrum, Steven J. Ackerman
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/19/10245