Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways
Fangchinoline (FCN) derived from Stephaniae tetrandrine S. Moore can be employed to treat fever, inflammation, rheumatism arthralgia, edema, dysuria, athlete’s foot, and swollen wet sores. FCN can exhibit a plethora of anti-neoplastic effects although its precise mode of action still remai...
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MDPI AG
2019-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/17/3127 |
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| author | Young Yun Jung Muthu K. Shanmugam Arunachalam Chinnathambi Sulaiman Ali Alharbi Omar H.M. Shair Jae-Young Um Gautam Sethi Kwang Seok Ahn |
| author_facet | Young Yun Jung Muthu K. Shanmugam Arunachalam Chinnathambi Sulaiman Ali Alharbi Omar H.M. Shair Jae-Young Um Gautam Sethi Kwang Seok Ahn |
| author_sort | Young Yun Jung |
| collection | DOAJ |
| description | Fangchinoline (FCN) derived from Stephaniae tetrandrine S. Moore can be employed to treat fever, inflammation, rheumatism arthralgia, edema, dysuria, athlete’s foot, and swollen wet sores. FCN can exhibit a plethora of anti-neoplastic effects although its precise mode of action still remains to be deciphered. Nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) can closely regulate carcinogenesis and thus we analyzed the possible action of FCN may have on these two signaling cascades in tumor cells. The effect of FCN on NF-κB and AP-1 signaling cascades and its downstream functions was deciphered using diverse assays in both human chronic myeloid leukemia (KBM5) and multiple myeloma (U266). FCN attenuated growth of both leukemic and multiple myeloma cells and repressed NF-κB, and AP-1 activation through diverse mechanisms, including attenuation of phosphorylation of IκB kinase (IKK) and p65. Furthermore, FCN could also cause significant enhancement in TNFα-driven apoptosis as studied by various molecular techniques. Thus, FCN may exhibit potent anti-neoplastic effects by affecting diverse oncogenic pathways and may be employed as pro-apoptotic agent against various malignancies. |
| first_indexed | 2024-12-13T08:12:33Z |
| format | Article |
| id | doaj.art-4da096d95bd34b70bb5124fdc6470710 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T08:12:33Z |
| publishDate | 2019-08-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4da096d95bd34b70bb5124fdc64707102022-12-21T23:54:11ZengMDPI AGMolecules1420-30492019-08-012417312710.3390/molecules24173127molecules24173127Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 PathwaysYoung Yun Jung0Muthu K. Shanmugam1Arunachalam Chinnathambi2Sulaiman Ali Alharbi3Omar H.M. Shair4Jae-Young Um5Gautam Sethi6Kwang Seok Ahn7Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaFangchinoline (FCN) derived from Stephaniae tetrandrine S. Moore can be employed to treat fever, inflammation, rheumatism arthralgia, edema, dysuria, athlete’s foot, and swollen wet sores. FCN can exhibit a plethora of anti-neoplastic effects although its precise mode of action still remains to be deciphered. Nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) can closely regulate carcinogenesis and thus we analyzed the possible action of FCN may have on these two signaling cascades in tumor cells. The effect of FCN on NF-κB and AP-1 signaling cascades and its downstream functions was deciphered using diverse assays in both human chronic myeloid leukemia (KBM5) and multiple myeloma (U266). FCN attenuated growth of both leukemic and multiple myeloma cells and repressed NF-κB, and AP-1 activation through diverse mechanisms, including attenuation of phosphorylation of IκB kinase (IKK) and p65. Furthermore, FCN could also cause significant enhancement in TNFα-driven apoptosis as studied by various molecular techniques. Thus, FCN may exhibit potent anti-neoplastic effects by affecting diverse oncogenic pathways and may be employed as pro-apoptotic agent against various malignancies.https://www.mdpi.com/1420-3049/24/17/3127fangchinolineNF-κBAP-1cancerapoptosis |
| spellingShingle | Young Yun Jung Muthu K. Shanmugam Arunachalam Chinnathambi Sulaiman Ali Alharbi Omar H.M. Shair Jae-Young Um Gautam Sethi Kwang Seok Ahn Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways Molecules fangchinoline NF-κB AP-1 cancer apoptosis |
| title | Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways |
| title_full | Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways |
| title_fullStr | Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways |
| title_full_unstemmed | Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways |
| title_short | Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways |
| title_sort | fangchinoline a bisbenzylisoquinoline alkaloid can modulate cytokine impelled apoptosis via the dual regulation of nf κb and ap 1 pathways |
| topic | fangchinoline NF-κB AP-1 cancer apoptosis |
| url | https://www.mdpi.com/1420-3049/24/17/3127 |
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