Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism

Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism

Summary: The circulating metabolome provides unique insights into multiple sclerosis (MS) pathophysiology, but existing studies are relatively small or characterized limited metabolites. We test for differences in the metabolome between people with MS (PwMS; n = 637 samples) and healthy controls (HC...

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Bibliographic Details
Main Authors: Kathryn C. Fitzgerald, Matthew D. Smith, Sol Kim, Elias S. Sotirchos, Michael D. Kornberg, Morgan Douglas, Bardia Nourbakhsh, Jennifer Graves, Ramandeep Rattan, Laila Poisson, Mirela Cerghet, Ellen M. Mowry, Emmanuelle Waubant, Shailendra Giri, Peter A. Calabresi, Pavan Bhargava
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports Medicine
Subjects:
multiple sclerosis
metabolomics
aromatic amino acid
gut microbiome
metabotoxin
metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S266637912100286X

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http://www.sciencedirect.com/science/article/pii/S266637912100286X

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