Advanced 3D dynamic culture system with transforming growth factor-β3 enhances production of potent extracellular vesicles with modified protein cargoes via upregulation of TGF-β signaling

Advanced 3D dynamic culture system with transforming growth factor-β3 enhances production of potent extracellular vesicles with modified protein cargoes via upregulation of TGF-β signaling

Introduction: Mesenchymal stromal cells (MSCs) release extracellular vesicles (MSC-EVs) containing various cargoes. Although MSC-EVs show significant therapeutic effects, the low production of EVs in MSCs hinders MSC-EV-mediated therapeutic development. Objectives: Here, we developed an advanced thr...

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Bibliographic Details
Main Authors: Kyung Min Lim, Sehee Kim, Jeonghun Yeom, Yujin Choi, Yoonjoo Lee, Jongyub An, Minchan Gil, Ahmed Abdal Dayem, Kyeongseok Kim, Geun-Ho Kang, Aram Kim, Kwonho Hong, Kyunggon Kim, Ssang-Goo Cho
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Advanced Research
Subjects:
Extracellular vesicles
MSC spheroids
Advanced 3D dynamic culture with TGF-β3
TGF-β signaling
Quantitative proteomic analysis
Enhanced regenerative capacity
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222002077

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http://www.sciencedirect.com/science/article/pii/S2090123222002077

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