Template-based modeling of insect odorant receptors outperforms AlphaFold3 for ligand binding predictions

Abstract Insects rely on odorant receptors (ORs) to detect and respond to volatile environmental cues, so the ORs are attracting increasing interest as potential targets for pest control. However, experimental analysis of their structures and functions faces significant challenges. Computational met...

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Bibliographic Details
Main Authors: Amara Jabeen, John Graham Oakeshott, Siu Fai Lee, Shoba Ranganathan, Phillip W. Taylor
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-80094-x