MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells

MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells

Background The MUC1-C protein evolved in mammals to protect barrier tissues from loss of homeostasis; however, MUC1-C promotes oncogenesis in association with chronic inflammation. Aberrant expression of MUC1-C in cancers has been linked to depletion and dysfunction of T cells in the tumor microenvi...

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Bibliographic Details
Main Authors: Satoshi Ishikawa, Donald Kufe, Constantine Mitsiades, Nami Yamashita, Atsushi Fushimi, Atrayee Bhattacharya, Yoshihiro Morimoto, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky
Format: Article
Language:English
Published: BMJ Publishing Group 2023-02-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/2/e006238.full

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https://jitc.bmj.com/content/11/2/e006238.full

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