TNFR2 expression on CD25hiFOXP3+ T cells induced upon TCR stimulation of CD4 T cells identifies maximal cytokine-producing effectors.

TNFR2 expression on CD25hiFOXP3+ T cells induced upon TCR stimulation of CD4 T cells identifies maximal cytokine-producing effectors.

In this study, we show that CD25hiTNFR2+ cells can be rapidly generated in vitro from circulating CD4 lymphocytes by polyclonal stimuli anti-CD3 in the presence of anti-CD28. The in vitro induced CD25hiTNFR2+ T cells express a conventional Treg phenotype FOXP3+CTLA4+CD127lo/-, but produce effector a...

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Bibliographic Details
Main Authors: Chindu eGovindaraj, Karen eScalzo-Inguanti, Anja eScholzen, Shuo eLi, Magdalena ePlebanski
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Immunology
Subjects:
Foxp3
regulatory T cells
Th1
Effector Cells
TNFR2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00233/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00233/full

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