Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NAA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study

Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NAA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study

BackgroundThe aim of this study was to evaluate the relationship between changes in proton magnetic resonance spectroscopy (1H-MRS) parameters at the start of the index episode recovery phase and at recurrence in patients with recurrent depression who were treated with prolonged maintenance therapy....

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Bibliographic Details
Main Authors: Neven Henigsberg, Helena Šarac, Marko Radoš, Milan Radoš, David Ozretić, Tamara Foro, Viktorija Erdeljić Turk, Pero Hrabač, Maja Bajs Janović, Benedict Rak, Petra Kalember
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Psychiatry
Subjects:
depression
recurrence
maintenance therapy
antidepressants
magnetic resonance spectroscopy
Online Access:http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00277/full

Internet

http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00277/full

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