Proteome-wide landscape of solubility limits in a bacterial cell

Abstract Proteins are prone to aggregate when expressed above their solubility limits. Aggregation may occur rapidly, potentially as early as proteins emerge from the ribosome, or slowly, following synthesis. However, in vivo data on aggregation rates are scarce. Here, we classified the Escherichia...

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Bibliographic Details
Main Authors: Ádám Györkei, Lejla Daruka, Dávid Balogh, Erika Őszi, Zoltán Magyar, Balázs Szappanos, Gergely Fekete, Mónika Fuxreiter, Péter Horváth, Csaba Pál, Bálint Kintses, Balázs Papp
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10427-1