Preclinical animal studies in ischemic stroke: Challenges and some solutions

Preclinical animal studies in ischemic stroke: Challenges and some solutions

Abstract Despite the impressive efficacies demonstrated in preclinical research, hundreds of potentially neuroprotective drugs have failed to provide effective neuroprotection for ischemic stroke in human clinical trials. Lack of a powerful animal model for human ischemic stroke could be a major rea...

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Bibliographic Details
Main Authors: Sunil K. Narayan, Simy GraceCherian, Prakash BabuPhaniti, Saravana BabuChidambaram, A. Hannah RachelVasanthi, Murugesan Arumugam
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Animal Models and Experimental Medicine
Subjects:
cerebral ischemia
circle of Willis
focal ischemic models
functional assessment tests
neuroprotection
preclinical model
Online Access:https://doi.org/10.1002/ame2.12166

Internet

https://doi.org/10.1002/ame2.12166

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