Preclinical animal studies in ischemic stroke: Challenges and some solutions
Abstract Despite the impressive efficacies demonstrated in preclinical research, hundreds of potentially neuroprotective drugs have failed to provide effective neuroprotection for ischemic stroke in human clinical trials. Lack of a powerful animal model for human ischemic stroke could be a major rea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12166 |
| _version_ | 1818742641338089472 |
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| author | Sunil K. Narayan Simy GraceCherian Prakash BabuPhaniti Saravana BabuChidambaram A. Hannah RachelVasanthi Murugesan Arumugam |
| author_facet | Sunil K. Narayan Simy GraceCherian Prakash BabuPhaniti Saravana BabuChidambaram A. Hannah RachelVasanthi Murugesan Arumugam |
| author_sort | Sunil K. Narayan |
| collection | DOAJ |
| description | Abstract Despite the impressive efficacies demonstrated in preclinical research, hundreds of potentially neuroprotective drugs have failed to provide effective neuroprotection for ischemic stroke in human clinical trials. Lack of a powerful animal model for human ischemic stroke could be a major reason for the failure to develop successful neuroprotective drugs for ischemic stroke. This review recapitulates the available cerebral ischemia animal models, provides an anatomical comparison of the circle of Willis of each species, and describes the functional assessment tests used in these ischemic stroke models. The distinct differences between human ischemic stroke and experimental stroke in available animal models is explored. Innovative animal models more closely resembling human strokes, better techniques in functional outcome assessment and better experimental designs generating clearer and stronger evidence may help realise the development of truly neuroprotective drugs that will benefit human ischemic stroke patients. This may involve use of newer molecules or revisiting earlier studies with new experimental designs. Translation of any resultant successes may then be tested in human clinical trials with greater confidence and optimism. |
| first_indexed | 2024-12-18T02:15:45Z |
| format | Article |
| id | doaj.art-4db3fd17d015454e92f2f87c03ee0901 |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-12-18T02:15:45Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-4db3fd17d015454e92f2f87c03ee09012022-12-21T21:24:22ZengWileyAnimal Models and Experimental Medicine2576-20952021-06-014210411510.1002/ame2.12166Preclinical animal studies in ischemic stroke: Challenges and some solutionsSunil K. Narayan0Simy GraceCherian1Prakash BabuPhaniti2Saravana BabuChidambaram3A. Hannah RachelVasanthi4Murugesan Arumugam5Comprehensive Stroke Care and Neurobiology Centre, Department of Neurology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry IndiaComprehensive Stroke Care and Neurobiology Centre, Department of Neurology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry IndiaDepartment of Biotechnology & School of Medical Sciences University of Hyderabad Hyderabad IndiaDepartment of Pharmacology JSS Medical College Mysore IndiaDepartment of Biotechnology School of Life science University of Pondicherry Pondicherry IndiaComprehensive Stroke Care and Neurobiology Centre, Department of Neurology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry IndiaAbstract Despite the impressive efficacies demonstrated in preclinical research, hundreds of potentially neuroprotective drugs have failed to provide effective neuroprotection for ischemic stroke in human clinical trials. Lack of a powerful animal model for human ischemic stroke could be a major reason for the failure to develop successful neuroprotective drugs for ischemic stroke. This review recapitulates the available cerebral ischemia animal models, provides an anatomical comparison of the circle of Willis of each species, and describes the functional assessment tests used in these ischemic stroke models. The distinct differences between human ischemic stroke and experimental stroke in available animal models is explored. Innovative animal models more closely resembling human strokes, better techniques in functional outcome assessment and better experimental designs generating clearer and stronger evidence may help realise the development of truly neuroprotective drugs that will benefit human ischemic stroke patients. This may involve use of newer molecules or revisiting earlier studies with new experimental designs. Translation of any resultant successes may then be tested in human clinical trials with greater confidence and optimism.https://doi.org/10.1002/ame2.12166cerebral ischemiacircle of Willisfocal ischemic modelsfunctional assessment testsneuroprotectionpreclinical model |
| spellingShingle | Sunil K. Narayan Simy GraceCherian Prakash BabuPhaniti Saravana BabuChidambaram A. Hannah RachelVasanthi Murugesan Arumugam Preclinical animal studies in ischemic stroke: Challenges and some solutions Animal Models and Experimental Medicine cerebral ischemia circle of Willis focal ischemic models functional assessment tests neuroprotection preclinical model |
| title | Preclinical animal studies in ischemic stroke: Challenges and some solutions |
| title_full | Preclinical animal studies in ischemic stroke: Challenges and some solutions |
| title_fullStr | Preclinical animal studies in ischemic stroke: Challenges and some solutions |
| title_full_unstemmed | Preclinical animal studies in ischemic stroke: Challenges and some solutions |
| title_short | Preclinical animal studies in ischemic stroke: Challenges and some solutions |
| title_sort | preclinical animal studies in ischemic stroke challenges and some solutions |
| topic | cerebral ischemia circle of Willis focal ischemic models functional assessment tests neuroprotection preclinical model |
| url | https://doi.org/10.1002/ame2.12166 |
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