Modelling hCDKL5 Heterologous Expression in Bacteria

Modelling hCDKL5 Heterologous Expression in Bacteria

hCDKL5 refers to the human cyclin-dependent kinase like 5 that is primarily expressed in the brain. Mutations in its coding sequence are often causative of hCDKL5 deficiency disorder, a devastating neurodevelopmental disorder currently lacking a cure. The large-scale recombinant production of hCDKL5...

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Bibliographic Details
Main Authors: Marco Fondi, Stefano Gonzi, Mikolaj Dziurzynski, Paola Turano, Veronica Ghini, Marzia Calvanese, Andrea Colarusso, Concetta Lauro, Ermenegilda Parrilli, Maria Luisa Tutino
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Metabolites
Subjects:
CDKL5
genome-scale metabolic modelling
protein production
Online Access:https://www.mdpi.com/2218-1989/11/8/491

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https://www.mdpi.com/2218-1989/11/8/491

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