Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses

Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses

Abstract The causal relationships between plasma metabolites and cholelithiasis/cholecystitis risks remain elusive. Using two-sample Mendelian randomization, we found that genetic proxied plasma campesterol level showed negative correlation with the risk of both cholelithiasis and cholecystitis. Fur...

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Bibliographic Details
Main Authors: Jiarui Mi, Qingwei Jiang, Zhengwei Qi, Zhengye Liu, Xiaoyin Bai, Xia Zheng, Jiaguo Wu, Yanfei Fang, Aiming Yang, Haotian Chen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Human Genomics
Subjects:
Cholelithiasis
Cholecystitis
Campesterol
Mendelian randomization
Colocalization analysis
Risk factor
Online Access:https://doi.org/10.1186/s40246-024-00583-y

Internet

https://doi.org/10.1186/s40246-024-00583-y

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