Acute high-fat diet impairs macrophage-supported intestinal damage resolution

Acute high-fat diet impairs macrophage-supported intestinal damage resolution

Chronic exposure to high-fat diets (HFD) worsens intestinal disease pathology, but acute effects of HFD in tissue damage remain unclear. Here, we used short-term HFD feeding in a model of intestinal injury and found sustained damage with increased cecal dead neutrophil accumulation, along with dieta...

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Bibliographic Details
Main Authors: Andrea A. Hill, Myunghoo Kim, Daniel F. Zegarra-Ruiz, Lin-Chun Chang, Kendra Norwood, Adrien Assié, Wan-Jung H. Wu, Michael C. Renfroe, Hyo Wong Song, Angela M. Major, Buck S. Samuel, Joseph M. Hyser, Randy S. Longman, Gretchen E. Diehl
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-02-01
Series:JCI Insight
Subjects:
Immunology
Online Access:https://doi.org/10.1172/jci.insight.164489

Internet

https://doi.org/10.1172/jci.insight.164489

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