Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions

Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions

Abstract Severely immunocompromised NOD.Cg‐PrkdcscidIl2rgtm1Sug (NOG) mice are among the ideal animal recipients for generation of human cancer models. Transplantation of human solid tumors having abundant tumor‐infiltrating lymphocytes (TILs) can induce xenogeneic graft‐versus‐host disease (xGvHD)...

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Bibliographic Details
Main Authors: Seyed Mostafa Monzavi, Ahad Muhammadnejad, Maryam Behfar, Amir Arsalan Khorsand, Samad Muhammadnejad, Abdol‐Mohammad Kajbafzadeh
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Animal Models and Experimental Medicine
Subjects:
graft‐versus‐host disease
patient‐derived xenograft models
tumor‐infiltrating lymphocytes
Wilms' tumor
Online Access:https://doi.org/10.1002/ame2.12254

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