Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

<p>Abstract</p> <p>Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-tumor strategy. The current study aims to identify small molecule kinase i...

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Bibliographic Details
Main Authors: van der Kuip Heiko, Friedel Godehard, Sonnenberg Maike, Mürdter Thomas E, Schmid Jens O, Haubeiss Silke, Aulitzky Walter E
Format: Article
Language:English
Published: BMC 2010-06-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/168

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http://www.molecular-cancer.com/content/9/1/168

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