Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis

Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis

Dysfunction of the vascular angiocrine system is critically involved in regenerative defects and fibrosis of injured organs. Previous studies have identified various angiocrine factors and found that risk factors such as aging and metabolic disorders can disturb the vascular angiocrine system in fib...

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Bibliographic Details
Main Authors: Xiangqi Chen, Han Wang, Chuan Wu, Xiaoyan Li, Xiaojuan Huang, Yafeng Ren, Qiang Pu, Zhongwei Cao, Xiaoqiang Tang, Bi-Sen Ding
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Lung fibrosis
Vascular endothelial cells
AMPK
H2S
PAI-1
YAP
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000144

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http://www.sciencedirect.com/science/article/pii/S2213231724000144

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