Valine-Induced Isoleucine Starvation in Escherichia coli K-12 Studied by Spike-In Normalized RNA Sequencing

Valine-Induced Isoleucine Starvation in Escherichia coli K-12 Studied by Spike-In Normalized RNA Sequencing

Escherichia coli cells respond to a period of famine by globally reorganizing their gene expression. The changes are known as the stringent response, which is orchestrated by the alarmone ppGpp that binds directly to RNA polymerase. The resulting changes in gene expression are particularly well stud...

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Bibliographic Details
Main Authors: Bertil Gummesson, Shiraz Ali Shah, Alexander Skov Borum, Mathias Fessler, Namiko Mitarai, Michael Askvad Sørensen, Sine Lo Svenningsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
stringent response
deep RNA sequencing
whole-cell spike-in normalization
ribosomal RNA degradation
transcriptome
ppGpp
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00144/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.00144/full

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