Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis

Benzimidazole-2-carbamates (BZ, e.g., albendazole; ALB), which bind β-tubulin to disrupt microtubule polymerization, are one of two primary compound classes used to treat giardiasis. In most parasitic nematodes and fungi, BZ-resistance is caused by β-tubulin mutations and its molecular mode of actio...

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Bibliographic Details
Main Authors: Qiao Su, Louise Baker, Samantha Emery, Balu Balan, Brendan Ansell, Swapnil Tichkule, Ivo Mueller, Staffan G. Svärd, Aaron Jex
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221132072300012X