Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis
Benzimidazole-2-carbamates (BZ, e.g., albendazole; ALB), which bind β-tubulin to disrupt microtubule polymerization, are one of two primary compound classes used to treat giardiasis. In most parasitic nematodes and fungi, BZ-resistance is caused by β-tubulin mutations and its molecular mode of actio...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-08-01
|
Series: | International Journal for Parasitology: Drugs and Drug Resistance |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221132072300012X |