Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s disease

Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s disease

Background: Vagus nerve stimulation (VNS) modifies brain rhythms in the locus coeruleus (LC) via the solitary nucleus. Degeneration of the LC in Parkinson’s disease (PD) is an early catalyst of the spreading neurodegenerative process, suggesting that stimulating LC output with VNS has the potential...

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Bibliographic Details
Main Authors: Ariana Q. Farrand, Ryan S. Verner, Ryan M. McGuire, Kristi L. Helke, Vanessa K. Hinson, Heather A. Boger
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Brain Stimulation
Subjects:
Parkinson’s disease
Vagus nerve stimulation
Nigrostriatal system
Dopamine
Locus coeruleus
Norepinephrine
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X20301960

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http://www.sciencedirect.com/science/article/pii/S1935861X20301960

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