Tryptophan-degrading enzymes in tumoral immune resistance
Tryptophan is required for T lymphocyte effector functions. Its degradation is one of the mechanisms selected by tumors to resist immune destruction. Two enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase 1 (IDO1), control tryptophan degradation through the kynurenine pathway....
| 主要な著者: | , |
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
Frontiers Media S.A.
2016-11-01
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| シリーズ: | Frontiers in Immunology |
| 主題: | |
| オンライン･アクセス: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00034/full |