Biochemical and immunological characterization of an ETEC CFA/I adhesin cholera toxin B subunit chimera.

Surface-expressed colonization factors and their subunits are promising candidates for inclusion into a multivalent vaccine targeting enterotoxigenic Escherichia coli (ETEC), a leading cause of acute bacterial diarrhea in developing regions. However, soluble antigens are often poorly immunogenic in...

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Bibliographic Details
Main Authors: Michael G Jobling, Steven T Poole, Fatima Rasulova-Lewis, Aisling O'Dowd, Annette L McVeigh, Amit Balakrishnan, Stephanie A Sincock, Michael G Prouty, Randall K Holmes, Stephen J Savarino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0230138