Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration

Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration

Abstract Background Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer’s disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burd...

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Bibliographic Details
Main Authors: Ione O. C. Woollacott, Christina E. Toomey, Catherine Strand, Robert Courtney, Bridget C. Benson, Jonathan D. Rohrer, Tammaryn Lashley
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Frontotemporal dementia
Frontotemporal lobar degeneration
Microglia
Dystrophy
Neuroinflammation
Progranulin
Online Access:http://link.springer.com/article/10.1186/s12974-020-01907-0

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http://link.springer.com/article/10.1186/s12974-020-01907-0

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