Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats

Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats

Background The long‐term effects of dipeptidyl peptidase 4 (DPP4) inhibitors on blood pressure and cardiovascular and renal health remain controversial. Herein, we investigated the extended (>182 days) effects of DPP4 inhibition in a model of spontaneous hypertension, heart failure, diabetes mell...

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Bibliographic Details
Main Authors: Edwin K. Jackson, Zaichuan Mi, Delbert G. Gillespie, Dongmei Cheng, Stevan P. Tofovic
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
dipeptidyl peptidase 4 inhibitors
heart damage
hypertension
kidney damage
spontaneously hypertensive heart failure rats
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.020088

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https://www.ahajournals.org/doi/10.1161/JAHA.120.020088

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