Evaluation of the Anti-<i>Histoplasma capsulatum</i> Activity of Indole and Nitrofuran Derivatives and Their Pharmacological Safety in Three-Dimensional Cell Cultures

Evaluation of the Anti-<i>Histoplasma capsulatum</i> Activity of Indole and Nitrofuran Derivatives and Their Pharmacological Safety in Three-Dimensional Cell Cultures

<i>Histoplasma capsulatum</i> is a fungus that causes histoplasmosis. The increased evolution of microbial resistance and the adverse effects of current antifungals help new drugs to emerge. In this work, fifty-four nitrofurans and indoles were tested against the <i>H. capsulatum&l...

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Main Authors: Carolina Orlando Vaso, Níura Madalena Bila, Fabiana Pandolfi, Daniela De Vita, Martina Bortolami, Jean Lucas Carvalho Bonatti, Rosângela Aparecida De Moraes Silva, Larissa Naiara Carvalho Gonçalves, Valeria Tudino, Roberta Costi, Roberto Di Santo, Maria José Soares Mendes-Giannini, Caroline Barcelos Costa-Orlandi, Luigi Scipione, Ana Marisa Fusco-Almeida
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
<i>Histoplasma capsulatum</i>
three-dimensional models
nitrofurans
indoles
pharmacological replacement
mechanisms of action
Online Access:https://www.mdpi.com/1999-4923/14/5/1043

Internet

https://www.mdpi.com/1999-4923/14/5/1043

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