The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance

The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance

The metal ion transporter ZIP8 (SLC39A8) mediates cellular uptake of vital divalent metal ions. Genome-wide association studies (GWAS) showed that the single-nucleotide polymorphism (SNP) variant A391T (rs13107325) is associated with numerous human traits, including reduced arterial blood pressure,...

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Bibliographic Details
Main Authors: Sophia N. Verouti, Jonai Pujol-Giménez, Paola Bermudez-Lekerika, Laeticia Scherler, Rajesh Bhardwaj, Aurélien Thomas, Sébastien Lenglet, Mark Siegrist, Willy Hofstetter, Daniel G. Fuster, Matthias A. Hediger, Geneviève Escher, Bruno Vogt
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Physiology
Subjects:
ZIP8
blood pressure
glucose
SLC39A8
rs13107325
divalent metal ions
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.912277/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.912277/full

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