Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes [version 1; peer review: 2 approved]

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes [version 1; peer review: 2 approved]

Background: Schistosoma mansoni, a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that is carefully controlled by both genetic and epigenetic processes. As inhibition of S. mansoni epigenetic machine...

Full description

Bibliographic Details
Main Authors: Iain W. Chalmers, Christoph Grunau, Josephine Forde-Thomas, Karl F. Hoffmann, Andrea Brancale, Cassandra A. Celatka, Gilda Padalino, Jay H. Kalin, Hugh Y. Rienhoff Jr., Damien Lassalle, Philip A. Cole
Format: Article
Language:English
Published: Wellcome 2023-03-01
Series:Wellcome Open Research
Subjects:
Lysine Specific Demethylase 1
epigenetics
ATAC-seq
anthelmintics
eng
Online Access:https://wellcomeopenresearch.org/articles/8-146/v1

Internet

https://wellcomeopenresearch.org/articles/8-146/v1

Similar Items