Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors

The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and cell death. Therefore, JNK represents an attractive target for therapeutic interve...

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Bibliographic Details
Main Authors: Igor A. Schepetkin, Anastasia R. Kovrizhina, Ksenia S. Stankevich, Andrei I. Khlebnikov, Liliya N. Kirpotina, Mark T. Quinn, Matthew J. Cook
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
anti-inflammatory
11H-indeno[1,2-b]quinoxalin-11-one
interleukin-6
c-Jun N-terminal kinase
nuclear factor-κB
oxime
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.958687/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.958687/full

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