Distinct Spatio-Temporal Dynamics of Tumor-Associated Neutrophils in Small Tumor Lesions

Distinct Spatio-Temporal Dynamics of Tumor-Associated Neutrophils in Small Tumor Lesions

Across a majority of cancer types tumor-associated neutrophils (TAN) are linked with poor prognosis. However, the underlying mechanisms, especially the intratumoral behavior of TAN, are largely unknown. Using intravital multiphoton imaging on a mouse model with neutrophil-specific fluorescence, we m...

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Bibliographic Details
Main Authors: Simon Sody, Mohib Uddin, Anika Grüneboom, André Görgens, Bernd Giebel, Matthias Gunzer, Sven Brandau
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
tumor-associated neutrophils
neutrophil granulocytes
intravital imaging
multiphoton microscopy
tumor microenvironment
tumor immunology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01419/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01419/full

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