Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

Abstract Clinical studies indicate that systemic infections accelerate cognitive decline in Alzheimer’s disease. Animal models suggest that this may be due to enhanced pro-inflammatory changes in the brain. We have performed a post-mortem human study to determine whether systemic infection modifies...

Full description

Bibliographic Details
Main Authors: Sonja Rakic, Yat M. A. Hung, Matthew Smith, Denise So, Hannah M. Tayler, William Varney, Joe Wild, Scott Harris, Clive Holmes, Seth Love, William Stewart, James A. R. Nicoll, Delphine Boche
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Systemic infection
Neuroinflammation
Human brain
Microglia
Online Access:http://link.springer.com/article/10.1186/s40478-018-0592-3

Internet

http://link.springer.com/article/10.1186/s40478-018-0592-3

Similar Items