Methylprednisolone Inhibits Autophagy of Vascular Endothelial Cells in Rat Femoral Head Via PI3K/Akt/mTOR Pathway

Methylprednisolone Inhibits Autophagy of Vascular Endothelial Cells in Rat Femoral Head Via PI3K/Akt/mTOR Pathway

Objective To study the relationship between vascular endothelial cells (VEC) and autophagy, and its regulatory mechanism in steroid‐induced avascular necrosis of the femoral head (SANFH). Methods In cell experiment, VEC were isolated and cultured from the femoral head of Sprague–Dawley rats and divi...

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Bibliographic Details
Main Authors: Bo‐yong Jang, Shi‐bing Guo, Rui Bai, Wan‐lin Liu, Yu‐lin Gong, Zhen‐qun Zhao
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Orthopaedic Surgery
Subjects:
Autophagy
PI3K/Akt/mTOR
RNA interference
Steroid‐induced avascular necrosis of the femoral head
Vascular endothelial cells
Online Access:https://doi.org/10.1111/os.13369

Internet

https://doi.org/10.1111/os.13369

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