MCP-1 and murine prion disease: Separation of early behavioural dysfunction from overt clinical disease

MCP-1 and murine prion disease: Separation of early behavioural dysfunction from overt clinical disease

Prion diseases are chronic, fatal neurodegenerative conditions of the CNS. We have investigated the role of monocyte chemoattractant protein-1 (MCP-1) in the ME7 model of murine prion disease. MCP-1 expression increased in the CNS throughout disease progression and was positively correlated with mic...

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Bibliographic Details
Main Authors: L.M. Felton, C. Cunningham, E.L. Rankine, S. Waters, D. Boche, V.H. Perry
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Prion disease
Scrapie
ME7
Behaviour
Microglia
Chemokine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000847

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