The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway

The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway

Leishmania amazonensis activates the NF-κB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated the role of PI3K/Akt in p50/p50 NF-κB activation and the effect on iNOS expression in L. amazonensis infection. The increased occupancy o...

Full description

Bibliographic Details
Main Authors: Teresa C. Calegari-Silva, Áislan C. Vivarini, Marina Miqueline, Guilherme R. R. M. Dos Santos, Karina Luiza Teixeira, Alessandra Mattos Saliba, Simone Nunes de Carvalho, Laís de Carvalho, Ulisses G. Lopes
Format: Article
Language:English
Published: The Royal Society 2015-01-01
Series:Open Biology
Subjects:
nuclear factor kappa b
leishmania
pi3k/akt
macrophage
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150118

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150118

Similar Items