Modulation of Doxorubicin Intracellular Accumulation and Anticancer Activity by Triterpene Glycoside Cucumarioside A<sub>2</sub>-2

Modulation of Doxorubicin Intracellular Accumulation and Anticancer Activity by Triterpene Glycoside Cucumarioside A<sub>2</sub>-2

The effect of treatment of Ehrlich ascites carcinoma (EAC) cells with multidrug resistance by holothurian triterpene glycoside, cucumarioside A<sub>2</sub>-2 (CA<sub>2</sub>-2) was evaluated. Calcein-AM efflux assay and doxorubicin (DOX) uptake and retention measurement in ca...

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Bibliographic Details
Main Authors: Ekaterina Menchinskaya, Tatiana Gorpenchenko, Alexandra Silchenko, Sergey Avilov, Dmitry Aminin
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Marine Drugs
Subjects:
cucumarioside a<sub>2</sub>-2
doxorubicin
ehrlich ascites carcinoma
mdr
sea cucumbers
triterpene glycosides
Online Access:https://www.mdpi.com/1660-3397/17/11/597

Internet

https://www.mdpi.com/1660-3397/17/11/597

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