HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia and neurons upon inflammasome activation and activates receptor for advanced glycation end products (RAGE) and toll-like receptor (TLR) 4 on the target cells. HMGB1/TLR4 axis is a key initiator of neuroinflamm...

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Bibliografske podrobnosti
Main Authors: Yam Nath Paudel, Mohd. Farooq Shaikh, Ayanabha Chakraborti, Yatinesh Kumari, Ángel Aledo-Serrano, Katina Aleksovska, Marina Koutsodontis Machado Alvim, Iekhsan Othman
Format: Article
Jezik:English
Izdano: Frontiers Media S.A. 2018-09-01
Serija:Frontiers in Neuroscience
Teme:
HMGB1
RAGE
TLR4
TBI
epilepsy
neuroinflammation
Online dostop:https://www.frontiersin.org/article/10.3389/fnins.2018.00628/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00628/full

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