Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks

Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks

Chromosomal DNA double-strand breaks (DSBs) are potentially lethal DNA lesions that pose a significant threat to genome stability and therefore need to be repaired to preserve genome integrity. Eukaryotic cells possess two main mechanisms for repairing DSBs: non-homologous end-joining (NHEJ) and hom...

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Bibliographic Details
Main Authors: Renata Tisi, Jacopo Vertemara, Giuseppe Zampella, Maria Pia Longhese
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Double-strand break (DSB)
DNA damage
MRX/MRN
Mre11
Rad50
Xrs2/NBS1
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020302762

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http://www.sciencedirect.com/science/article/pii/S2001037020302762

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